What causes lipomas?

Talk about anything and everything related to lipomas and related healthcare issues here.

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Guest

Re: What causes lipomas?

Post by Guest » Sat Oct 06, 2012 12:29 pm

Flipon: Your lump was probably not a lipoma, at least not a common monoclonal tumor lipoma. All of the different vitamin combinations have never been effective in the past in reducing common lipomas.
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Re: What causes lipomas?

Post by matt » Sat Oct 06, 2012 1:21 pm

Guest wrote:In the old days before the field of genetics had emerged, it was not possible to simply test an animals' genes for inherited defects. Now it is. So there is no longer any mystery about which mutations are inherited (germline) versus which are acquired (somatic.)

But it is interesting to look back on the literature of the old days to see how far knowledge has advanced since then.
Dear Guest, I'm afraid you didn't understand the quote I presented or purposedly twisted it.

There was a strain of rodents whose offspring often suffered from cancer when they got older. The researches presumed this was because of the inheritance.

Later on they did a test where they took the young rodents right after they had born and let them suckle the milk of a rodent in another strain in which cancers did not occur. These rodents never got any cancer!

This means that the only way the offspring could get cancer was after the birth via direct contact to their parents (e.g. milk).

I rest my case 8-)
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
Guest

Re: What causes lipomas?

Post by Guest » Sat Oct 06, 2012 7:32 pm

Matt: Back then they could not simply test the rats DNA to determine whether the cancer was inherited versus acquired. Today, we don't need to run the type of experiment described in your reference to make this distinction. It is quaint to look back now on the old days and imagine that these guys could confuse an inherited versus acquired cancer. But that was the state of the art back then. It was not like today, in which you could simply run a genetic test.

Turning to lipoma, it is now easy to see the mutation in at birth (or before) and then know that the lipoma was not due to a mutation acquired later in life.

Does this clarify?
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Re: What causes lipomas?

Post by matt » Sat Oct 06, 2012 8:16 pm

Guest: Haha, your words still don't change the fact what I repeated in my previous post. There's no need for the DNA testing. The rats got the tumor virus from the milk. Does this clarify?

And people weren't imbeciles back in the sixtees, I think they even went to the moon in the sixtees...
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
Guest

Re: What causes lipomas?

Post by Guest » Sun Oct 07, 2012 11:38 am

Matt: I am not disagreeing that the rats got the tumor virus from the milk. I agree with you. They came to this conclusion in a very different way than they would have today. Today they would simply run a DNA test and would not (unlike common lipoma) find any inherited mutation.
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Re: What causes lipomas?

Post by matt » Sun Oct 07, 2012 2:20 pm

Guest: They do not find inherited mutations in common lipomas either. At least they haven't been able to do so yet. I'm eagerly waiting for such results but it seems it's not going to happen...
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
Guest

Re: What causes lipomas?

Post by Guest » Sun Oct 07, 2012 5:04 pm

matt wrote:Guest: They do not find inherited mutations in common lipomas either. At least they haven't been able to do so yet. I'm eagerly waiting for such results but it seems it's not going to happen...

Matt: Just google one of the following

lipoma translocation

or

lipoma hmgic

or

Lipoma mutation

you will see information on the inherited lipoma mutations.

If you are unsure that these mutations are inherited, then do a quick google search on the difference between inherited (germline) versus acquired (somatic) mutations. You will see how they can tell the difference between the two. I am not sure if they still use the terms germline and somatic or if "inherited" versus "acquired" is more common now, but a few google searches can get you there.

Regards........
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Re: What causes lipomas?

Post by matt » Sun Oct 07, 2012 8:47 pm

Guest: Instead of me waisting my time googling, you link me a study..................?
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
flipon

Re: What causes lipomas?

Post by flipon » Tue Oct 09, 2012 6:11 am

Guest,

Maybe you are right about the vitamins or the lump. All I know is that I got this small lump or doughy ball the size of a pecan or walnut, that's disappearing right in front of me. It's under my skin and not attached to anything. Near my wrist area and on my left hand specifically. All I changed was this formulation. I thought I would have to surgery to get rid of it. I'm just happy that it's going away. I thought I might share my experiences since I was freaked out as much as everybody else when they got theirs and realized one day that it was shrinking. Hope, that one day somebody figures this out. I would really like to know since I might get another lump again.
Guest

Re: What causes lipomas?

Post by Guest » Tue Oct 09, 2012 12:50 pm

Flipon: Many things can cause lumps, not just lipoma. Many types of lumps disappear on their own. Lipomas, however, do not disappear on their own or from vitamins.
The rooster crows and then the sun rises. The rooster crowing was "the only thing that changed". But the rooster did not really cause the sun to rise.
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Re: What causes lipomas?

Post by matt » Tue Oct 09, 2012 2:46 pm

Guest: Maybe your roosters can now go and find me a study which clearly indicates that lipomas are inherited? Thanks and cockadoodledoo!
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
Guest

Re: What causes lipomas?

Post by Guest » Wed Oct 10, 2012 2:20 am

Some others have posted links to genetics articles....maybe a reader could do so now for Matt? Thanks.
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Re: What causes lipomas?

Post by matt » Wed Oct 10, 2012 6:18 am

I'm afraid Guest's desperate cry for help from others will not help now...

Guest is unable to provide such data since there isn't any. There is no such study on this board which would indicate that lipomas are genetically inherited in humans. It is only a suspicion which is repeated over an over again. Infact, only the opposite data exists like the rat's milk in the Nobel lecture or the absensence of the abnormal karyotype in FML.

Yes, there are translocations in most lipomas (some don't) and many times the translocation is associated with the high mobility group proteins like HMGA.

But not a single study states that a certain translocation was found from the parent in all his/her cells and they were able to find it from his/her children's cells also thus the lipoma gene was inherited. Why?


If an inherited mutation was the cause of lipomas don't you think it would have been found already?
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
griffo

Re: What causes lipomas?

Post by griffo » Tue Nov 06, 2012 9:13 am

Hi There,

Has anyone ever had a lipoma just disappear? I have had a lump on my shoulder for probably 8 years now. I've had it looked at by probably half a dozen GP's over that time who have all told me the same story - it's a Lipoma.

Recently however, I went on a course of Prednisolone and Doxycycline to treat a stubborn sinus infection. During the first course (4 days of 50mg Prednisolone, 4 days of 25mg) the Lipoma just disappeared. If anything i now have a slight depression where it was. After a couple of weeks it has not returned.

Is this something that has been documented before??
Curious

Re: What causes lipomas?

Post by Curious » Tue Nov 06, 2012 5:52 pm

Hi Matt,

First of all, thank you for setting up this board; I (and I'm sure many others) consider it to be a great resource.

That said, I'd just like to comment on the topic of genetics.

While, like you, I have yet to read through a study showing unequivocally that lipoma-formation is genetic, I'm stilll 100% convinced that it is in many, if not most, cases.

I understand that your parents may not have lipomas (though isn't it possible that one of them has a very mild case of lipomatosis). But even if they have no lipomas, and you do have some, how can you conclude that your lipomatosis isn't the result of chromosomal translocation? Isn't that how mutation works? Sometimes, in the process of reproduction, genetic mistakes are made... this is, according to theory, how we evolve, isn't it?

I would just say that, even if a virus or bacteria is at fault in your case, you are likely in the minority. Of course, I can't prove this, but it's probably far more likely than not that you share a similar genetic mutation to the rest of us.

I very much want for us to find a simple and effective treatment for this, but ignoring or refusing to accept what seems to be obvious is probably to our detriment. The reality is that "familial" multiple lipomatosis is called this way because it tends to run through families. This is certainly true in my case, and in the case of many people with this annoying condition.
curious

Re: What causes lipomas?

Post by curious » Tue Nov 06, 2012 5:57 pm

Hi Griffo,

Yes, spontaneous remission of a lipoma has been observed. Dr Herbst, a specialist in fat disorders, has seen it several times, I believe. She has mentioned, specifically, that doxycycline can have such an effect.
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Re: What causes lipomas?

Post by matt » Thu Nov 08, 2012 4:02 am

Curious, I take it you already read my previous post in which I suggest a method of how lipomatosis is transmitted inside family members? Microbes can be transmitted from animal to animal via different ways, like touching or drinking mother's milk. Microbes can also alter the DNA of a cell.

I admit - it does look like it's all genetic and that there's absolutely nothing we can do about it - but is it really? What if we are looking it from the wrong perspective? I honestly think everyone should read the Nobel article I linked in my previous post and really think about what we actually know about genetics and inheritance.

So until someone shows me a study which clearly indicates that a certain DNA mutation is responsible of lipomatosis I can't tell whether lipomatosis is a real genetically inherited disease or something else. Actually, I already know it's not possible since there are many mutations involved with lipomatosis. There isn't any single DNA mutation. Everybody's (also among lipomatosis patients and their tumors) karyotype is a little different.

And I don't quite like your idea that I would be somekind of a nature's freak or one-in-a-million when it comes to the lipomatosis. I mean, if it would turn out to be microbial based on me I would be more prone to believe it's microbial based on everyone.
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
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Re: What causes lipomas?

Post by matt » Thu Dec 27, 2012 1:37 pm

I find it interesting that there's a condition called the recurrent respiratory papillomatosis (or the Laryngeal papillomatosis) in which one develops multiple benign tumors (papillomas) along the epithelium of the upper respiratory tract including the larynx, the vocal cords, the arytenoids, the subglottis, and the trachea.

Image

This condition is known to be caused by the human papilloma virus (HPV). HPV causes also the human warts. Both papillomas and warts are often granular, thus resembling a little bit of a lipoma from the outside and like lipomas these tumors tend to recur even if surgically removed.

For some reason not everyone who has HPV (types 6 and 11) develop this condition.

Papillomatosis is not genetically inherited. Instead the researchers believe the human papilloma virus might be infected to the newborn during the vaginal child birth. Still, babies delivered by Caesarian section may get papillomatosis but it's more rare.

The symptoms onset can sometimes take years so the HPV does not necessarily cause tumors immediately.

The treatment is traditionally surgery but injectable antiviral substances have been tested. Still, none of the antiviral therapies have completely removed a tumor or even stopped the growth. Instead they have been able to slow down the growth.

It's also interesting that for some unknown reason the HPV prevalence is bimodal and greatest in humans when they are under one year old or in adolensence between 13 to 20 years.

Some of you will state this is totally irrelevant but others must notice some similarities when it comes to lipomatosis :roll:
Hi I'm Matt - the creator and owner of this site. I have dozens of small nasty lipomas all over. I've tried many treatments including surgery and Lipostabil injections. See my lipoma prevention supplement recommendations and please consider donating a small amount via PayPal (click the Donate button) to keep this site up and running. Thx!
anomalous

Re: What causes lipomas?

Post by anomalous » Sat Jan 05, 2013 1:37 am

Why don't you guys carry out your own research? You have a forum full of people. You could make a questionaire, ask for family history, other diseases, allergies, food habits, etc. If everyone in the forum fills it out, perhaps you discover something? Just an idea I got while checking out what a lipoma is, and ended up reading this thread.
Guest

Re: What causes lipomas?

Post by Guest » Sat Jan 05, 2013 9:16 pm

Hi. Here is the answer to your question. The reason that this doesn't make sense is that it has already been done, on a massive scale, by professional researchers. They found no environmental cause for common lipomatosis. That includes all lifestyle variables. One common thread that has been found: Most people with common lipomatosis have one of a handful of genetic mutations. There are some exceptions, and those exceptions are very interesting and therefore get written up in research journals because they are so unusual. But MOST people with COMMON LIPOMATOSIS have one of a few specific mutations.
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